HBV-related antigens(Peptide Antigen)

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SKU: CC10

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Description

Introduction

HBsAg (also called Bionanocapsule) is the surface antigen of Hepatitis B virus (HBV). HBsAg is known to be present in blood if HBV infected patients, and used as a important diagnostic maker of HBV infection. HBsAg forms a small lipid particle(diameter 50 to 60nm)in which many antigen protein are present. Each antigen protein has three domains, called S, Pre-S1 and Pre-S2. L-type antigen contains all the three domains, M-type antigen contains S- and Pre-S2, and S-type antigen consisted of only S-domains. During the process of HBV infection, Pre-S1 domain plays a key role for host (hepatic) cell recognition, and Pre-S2 domain is essential for cell penetration. In infected patients, hepatic cells produces a lot of non-infectious S-type HBsAg (HBV mimetics without genome). The detection of serum Pre-S2 and Pre-S1 antigen is, therefore, very important to reveal the mechanism of HBV infection. Beacle has over a decade of R&D history on HBsAg and related materials, and developed the production process of various HBsAgs . In this page, we introduce these HBsAg-related products.

General flyer for HBV-related antigens

Products listed in this page can be ordered directly to us through order form.

Properties of antigens

Our HBs antigens are all recombinant antigen produced in yeast or E.coli. Therefore, antigens shows stable quality, and does not cause HBV infections.

Types of antigens

 

1. Pre-S1 peptide
Pre-S1 peptide produced in E.coli. There are two types of products, one is tagged peptide and the other is no tagged peptide. In general, the former product is good for immunoassay use, and the latter for standard use. For each products, four peptides of different genotypes are available; genotype A, B, C and D. For detail please check Pre-S1 peptides datasheet.

2. Pre-S2 peptide
Pre-S2 peptide produced in E.coli. There are two types of products, one is tagged peptide and the other is no tagged peptide. In general, the former product is good for immunoassay use, and the latter for standard use. For each products, four peptides of different genotypes are available; genotype A, B, C and D. For detail please check Pre-S2 peptides datasheet.

3.Others
Other HBV antigens, and labeled products of above antigens are available on request. Please contact us from here.

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