SARS-COV-2 related products(N proteins)

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Based on over 10 years biotechnology research experience, Beacle developed SARS-COV-2 related products.
SARS-COV-2 is a virus having  an envelope structure. Several proteins including Spike (S) proteins are displayed on the envelope, and in the envelope  nucleus (N) protein make a complex with its RNA gene.   The infection is revealed to start form the binding of S protein’s SB domain to ACE2 receptors of host cells and subsequent viral enters into host cells through endocytosis.   Viral RNA is then released into cells by the aid of S protein’s S2 domain through  membrane fusion system. N protein is the most abundant protein of SARS-COV-2 and highly immunogenic,  and infected human often shows high antibody to N proteins. N protein is composed of three domains, called N terminus domain (NTD) related with RNA binding, C terminus domain (CTD) related with formation of complexes, and liner region of the two domains which is related with phosphorylation.  Many vaccines are developed against SARS-COV-2 infection, and all of them utilizes S protein as the target molecule.

Product outline

1. SARS-COV-2 antigens.  

N proteins
 NTD: N terminus domain of N protein produced in E. coli. Two types of proteins (thioredoxin-his tag and non-tag) are available.
 CTD: C terminus domain of N protein produced in E. coli. Two types of proteins (thioredoxin-his tag and non-tag) are available.
 full length N proteins: full length N protein produced in E. coli.  In addition to the original Wuhan type,  N proteins of 4 mutants, British, Brazil, South Africa, and India types are available.
For detail see datasheet

2. Anti-SARS-COV-2 antibody quantitative ELISA kit

Anti-N protein antibody ELISA kit
Antibodies that binds to full length N proteins are quantitatively measured by the kit using attached standard antibody. The kit utilizes our original antibody detection probe and highly sensitive.
For detail see datasheet(in preparation)

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